UBR1 Antibody

Product Specifications

Background

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

NCBI Gene ID

197131

Swiss Prot

Q8IWV7

Accession Number

Q8IWV7

Host

Rabbit

Reactivity

Mouse

Immunogen

This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

200 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

UBR1

NCBI Official Name

E3 ubiquitin-protein ligase UBR1

NCBI Organism

Homo sapiens

Background Reference 01

Elting, M., et al. Am. J. Med. Genet.146A (23), 3058-3061 (2008) :

Background Reference 02

Alkhouri, N., et al. World J. Gastroenterol. 14 (44) :6863-6866 (2008)

Background Reference 03

Yamaguchi, Y., et al. BMC Med. Genet. 9, 22 (2008) :

Background Reference 04

Schmidt, R.L., et al. Cancer Res. 67 (24) :11798-11810 (2007)

Other Product Names

E3 ubiquitin-protein ligase UBR1, 632-, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1

Tested Applications

Protein ID

73622071

Physical Properties

Liquid

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