MMEL1 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.

NCBI Gene ID

79258

Swiss Prot

Q495T6

Accession Number

Q495T6

Host

Rabbit

Reactivity

Human

Immunogen

This MMEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human MMEL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

89 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MMEL1

NCBI Official Name

Membrane metallo-endopeptidase-like 1

NCBI Organism

Homo sapiens

Background Reference 01

Van der Helm-van Mil, A.H., et al. Ann. Rheum. Dis. 69 (9) :1694-1696 (2010)

Background Reference 02

Hirschfield, G.M., et al. Nat. Genet. 42 (8) :655-657 (2010)

Background Reference 03

Stahl, E.A., et al. Nat. Genet. 42 (6) :508-514 (2010)

Background Reference 04

Dubois, P.C., et al. Nat. Genet. 42 (4) :295-302 (2010)

Other Product Names

Membrane metallo-endopeptidase-like 1, Membrane metallo-endopeptidase-like 2, NEP2 (m), Neprilysin II, NEPII, Neprilysin-2, NEP2, NL2, Membrane metallo-endopeptidase-like 1, soluble form, Neprilysin-2 secreted, NEP2 (s), MMEL1, MELL1, MMEL2, NEP2