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Chemokine Receptor D6 Antibody

Product Specifications

Background

CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

NCBI Gene ID

1238

Swiss Prot

O00590

Accession Number

O00590

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Chemokine Receptor D6 (CCBP2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-84 amino acids from the N-terminal region of human Chemokine Receptor D6 (CCBP2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction, Growth Factors

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

43 kDa

Fragment

Rabbit Ig

Symbol

ACKR2

NCBI Official Name

Atypical chemokine receptor 2

NCBI Organism

Homo sapiens

Background Reference 01

Kunkel, E.J., et al., J. Clin. Invest. 111 (7) :1001-1010 (2003) .

Background Reference 02

Fra, A.M., et al., J. Immunol. 170 (5) :2279-2282 (2003) .

Background Reference 03

Soler, D., et al., Blood 101 (5) :1677-1682 (2003) .

Background Reference 04

Nibbs, R.J., et al., Am. J. Pathol. 158 (3) :867-877 (2001) .

Other Product Names

Atypical chemokine receptor 2, C-C chemokine receptor D6, Chemokine receptor CCR-10, Chemokine receptor CCR-9, Chemokine-binding protein 2, Chemokine-binding protein D6, ACKR2, CCBP2, CCR10, CMKBR9, D6

Tested Applications

WB, IHC-P

Physical Properties

Liquid

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