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MMACHC Antibody

Product Specifications

Background

The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.

NCBI Gene ID

25974

Swiss Prot

Q9Y4U1

Accession Number

Q9Y4U1

Host

Rabbit

Reactivity

Human

Immunogen

This MMACHC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human MMACHC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-875

Calculated Molecular Weight

32 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MMACHC

NCBI Official Name

Methylmalonic aciduria and homocystinuria type C protein

NCBI Organism

Homo sapiens

Background Reference 01

Froese, D.S., et al. Mol. Genet. Metab. 100 (1) :29-36 (2010)

Background Reference 02

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Background Reference 03

Profitlich, L.E., et al. Mol. Genet. Metab. 98 (4) :344-348 (2009)

Background Reference 04

Kim, J., et al. J. Biol. Chem. 284 (48) :33418-33424 (2009)

Other Product Names

Methylmalonic aciduria and homocystinuria type C protein, MMACHC

Tested Applications

WB

Protein ID

85681045

Physical Properties

Liquid

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