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RRM1 Antibody

Product Specifications

Background

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

NCBI Gene ID

6240

Swiss Prot

P23921

Accession Number

P23921

Host

Rabbit

Reactivity

Human

Immunogen

This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-858

Calculated Molecular Weight

90 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RRM1

NCBI Official Name

Ribonucleoside-diphosphate reductase large subunit

NCBI Organism

Homo sapiens

Background Reference 01

Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16 (10) :770-777 (2010)

Background Reference 02

Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

Background Reference 03

Vinolas, N., et al. Lung Cancer (2010) In press :

Background Reference 04

Niida, H., et al. Genes Dev. 24 (4) :333-338 (2010)

Other Product Names

Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1

Tested Applications

WB

Protein ID

132608

Physical Properties

Liquid

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