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Mouse Irf3 Antibody

Product Specifications

Background

Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity) .

NCBI Gene ID

54131

Swiss Prot

P70671

Accession Number

P70671

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Inflammasomes

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-856

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Irf3

NCBI Official Name

Interferon regulatory factor 3

NCBI Organism

Mus musculus

Background Reference 01

Marichal, T., et al. J. Allergy Clin. Immunol. 126 (4) :836-844 (2010)

Background Reference 02

Menachery, V.D., et al. J. Virol. 84 (19) :9685-9694 (2010)

Background Reference 03

Carrigan, S.O., et al. J. Immunol. 185 (6) :3602-3609 (2010)

Background Reference 04

Wang, J., et al. J. Immunol. 185 (3) :1720-1729 (2010)

Other Product Names

Interferon regulatory factor 3, IRF-3, Irf3

Tested Applications

WB

Physical Properties

Liquid

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