RLIM Antibody

Product Specifications

Background

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified.

NCBI Gene ID

51132

Swiss Prot

Q9NVW2

Accession Number

Q9NVW2

Host

Rabbit

Reactivity

Human

Immunogen

This RLIM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-227 amino acids from the Central region of human RLIM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

69 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RLIM

NCBI Official Name

E3 ubiquitin-protein ligase RLIM

NCBI Organism

Homo sapiens

Background Reference 01

Jonkers, I., et al. Cell 139 (5) :999-1011 (2009)

Background Reference 02

Her, Y.R., et al. J. Biol. Chem. 284 (13) :8557-8566 (2009)

Background Reference 03

Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

Background Reference 04

Hiratani, I., et al. Development 130 (17) :4161-4175 (2003)

Other Product Names

E3 ubiquitin-protein ligase RLIM, 632-, LIM domain-interacting RING finger protein, RING finger LIM domain-binding protein, R-LIM, RING finger protein 12, Renal carcinoma antigen NY-REN-43, RLIM, RNF12