BMPR1A Antibody

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the C-terminal region of human BMPR1A.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Waite, K.A., et al., Hum. Mol. Genet. 12 (6) :679-684 (2003) . Zhou, X.P., et al., Am. J. Hum. Genet. 69 (4) :704-711 (2001) . Astrom, A.K., et al., Mamm. Genome 10 (3) :299-302 (1999) . ten Dijke, P., et al., Oncogene 8 (10) :2879-2887 (1993) . Ide, H., et al., Cytogenet. Cell Genet. 81 (3-4), 285-286 (1998) .

Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3