GPR77 Antibody

Product Specifications

Background

The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]) .

NCBI Gene ID

27202

Swiss Prot

Q9P296

Accession Number

Q9P296

Host

Rabbit

Reactivity

Human

Immunogen

This GPR77 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-325 amino acids from the C-terminal region of human GPR77.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Growth Factors

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

36 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

C5AR2

NCBI Official Name

C5a anaphylatoxin chemotactic receptor 2

NCBI Organism

Homo sapiens

Background Reference 01

Bamberg, C.E., et al. J. Biol. Chem. 285 (10) :7633-7644 (2010)

Background Reference 02

Cui, W., et al. Mol. Immunol. 46 (16) :3207-3217 (2009)

Background Reference 03

Cui, W., et al. Mol. Immunol. 46 (15) :3086-3098 (2009)

Background Reference 04

Scola, A.M., et al. Mol. Immunol. 46 (6) :1149-1162 (2009)

Other Product Names

C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77, C5AR2, C5L2, GPR77

Tested Applications

Protein ID

20137533

Physical Properties

Liquid

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