ATP1A3 Antibody

Product Specifications

Background

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.

NCBI Gene ID

478

Swiss Prot

P13637

Accession Number

P13637

Host

Rabbit

Reactivity

Human

Immunogen

This ATP1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-833 amino acids from the Central region of human ATP1A3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

112 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ATP1A3

NCBI Official Name

Sodium/potassium-transporting ATPase subunit alpha-3

NCBI Organism

Homo sapiens

Background Reference 01

Einholm, A.P., et al. J. Biol. Chem. 285 (34) :26245-26254 (2010)

Background Reference 02

Floyd, R.V., et al. Reprod Sci 17 (4) :366-376 (2010)

Background Reference 03

Hauck, C., et al. Eur. J. Pharmacol. 622 (1-3), 7-14 (2009) :

Background Reference 04

Blanco-Arias, P., et al. Hum. Mol. Genet. 18 (13) :2370-2377 (2009)

Other Product Names

Sodium/potassium-transporting ATPase subunit alpha-3, Na (+) /K (+) ATPase alpha-3 subunit, Na (+) /K (+) ATPase alpha (III) subunit, Sodium pump subunit alpha-3, ATP1A3