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TTPA Antibody

Product Specifications

Background

This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.

NCBI Gene ID

7274

Swiss Prot

P49638

Accession Number

P49638

Host

Rabbit

Reactivity

Human

Immunogen

This TTPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the Central region of human TTPA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

32 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TTPA

NCBI Official Name

Alpha-tocopherol transfer protein

NCBI Organism

Homo sapiens

Background Reference 01

Zhang, W.X., et al. Lipids 44 (7) :631-641 (2009)

Background Reference 02

Wright, M.E., et al. Cancer Res. 69 (4) :1429-1438 (2009)

Background Reference 03

Fusco, C., et al. J. Child Neurol. 23 (11) :1328-1330 (2008)

Background Reference 04

Rotzoll, D.E., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 140 (2) :183-191 (2008)

Other Product Names

Alpha-tocopherol transfer protein, Alpha-TTP, TTPA, TPP1

Tested Applications

WB

Protein ID

1351322

Physical Properties

Liquid

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