NEU1 Antibody

Product Specifications

Background

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein') . Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

NCBI Gene ID

4758

Swiss Prot

Q99519

Accession Number

Q99519

Host

Rabbit

Reactivity

Human

Immunogen

This NEU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-214 amino acids from the Central region of human NEU1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

45 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NEU1

NCBI Official Name

Sialidase-1

NCBI Organism

Homo sapiens

Background Reference 01

Caciotti, A., et al. J. Neurol. 256 (11) :1911-1915 (2009)

Background Reference 02

Bonten, E.J., et al. J. Biol. Chem. 284 (41) :28430-28441 (2009)

Background Reference 03

Barcellos, L.F., et al. PLoS Genet. (10), E1000696 (2009) :

Background Reference 04

Wang, J., et al. J. Neurochem. 111 (2) :547-554 (2009)

Other Product Names

Sialidase-1, Acetylneuraminyl hydrolase, G9 sialidase, Lysosomal sialidase, N-acetyl-alpha-neuraminidase 1, NEU1, NANH

Tested Applications

Protein ID

17368612

Physical Properties

Liquid

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