SCNN1B Antibody

Product Specifications

Background

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.

NCBI Gene ID

6338

Swiss Prot

P51168

Accession Number

P51168

Host

Rabbit

Reactivity

Human

Immunogen

This SCNN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-332 amino acids from the Central region of human SCNN1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

73 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SCNN1B

NCBI Official Name

Amiloride-sensitive sodium channel subunit beta

NCBI Organism

Homo sapiens

Background Reference 01

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 02

Song, W., et al. J. Biol. Chem. 285 (13) :9716-9728 (2010)

Background Reference 03

Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

Background Reference 04

McGeachie, M., et al. Circulation 120 (24) :2448-2454 (2009)

Other Product Names

Amiloride-sensitive sodium channel subunit beta, Beta-NaCH, Epithelial Na (+) channel subunit beta, Beta-ENaC, ENaCB, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB, SCNN1B