PVR Antibody
Product Specifications
Background
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
5817
Swiss Prot
P15151
Accession Number
P15151
Host
Rabbit
Reactivity
Human
Immunogen
This PVR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human PVR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PVR
NCBI Official Name
Poliovirus receptor
NCBI Organism
Homo sapiens
Background Reference 01
Nakai, R., et al. Cancer Sci. 101 (5) :1326-1330 (2010)
Background Reference 02
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Background Reference 03
Stanietsky, N., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (42) :17858-17863 (2009)
Background Reference 04
Carlsten, M., et al. J. Immunol. 183 (8) :4921-4930 (2009)
Other Product Names
Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS
Tested Applications
WB
Protein ID
1346922
Physical Properties
Liquid
Frequently Asked Questions
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