PDCD6IP Antibody

Product Specifications

Background

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

NCBI Gene ID

10015

Swiss Prot

Q8WUM4

Accession Number

Q8WUM4

Host

Rabbit

Reactivity

Human

Immunogen

This PDCD6IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-570 amino acids from the Central region of human PDCD6IP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

96 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDCD6IP

NCBI Official Name

Programmed cell death 6-interacting protein

NCBI Organism

Homo sapiens

Background Reference 01

Shi, X., et al. Biochem. J. 431 (1) :93-102 (2010)

Background Reference 02

Irie, T., et al. Virology 405 (2) :334-341 (2010)

Background Reference 03

Sette, P., et al. J. Virol. 84 (16) :8181-8192 (2010)

Background Reference 04

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Other Product Names

Programmed cell death 6-interacting protein, PDCD6-interacting protein, ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95, PDCD6IP, AIP1, ALIX, KIAA1375