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YBX1 Antibody

Product Specifications

Background

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity) . Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro) . May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.

NCBI Gene ID

4904

Swiss Prot

P67809

Accession Number

P67809

Host

Rabbit

Reactivity

Human

Immunogen

This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human YBX1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-802

Calculated Molecular Weight

36 kDa

Fragment

Rabbit Ig

Symbol

YBX1

NCBI Official Name

Nuclease-sensitive element-binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Yu, Y.N., et al. Int. J. Oncol. 37 (2) :483-492 (2010)

Background Reference 02

Lovett, D.H., et al. Biochem. Biophys. Res. Commun. 398 (3) :482-488 (2010)

Background Reference 03

Takahashi, M., et al. Cancer Sci. 101 (6) :1367-1373 (2010)

Background Reference 04

Cobbold, L.C., et al. Oncogene 29 (19) :2884-2891 (2010)

Other Product Names

Nuclease-sensitive element-binding protein 1, CCAAT-binding transcription factor I subunit A, CBF-A, DNA-binding protein B, DBPB, Enhancer factor I subunit A, EFI-A, Y-box transcription factor, Y-box-binding protein 1, YB-1, YBX1, NSEP1, YB1

Tested Applications

WB, IF

Protein ID

54040031

Physical Properties

Liquid

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