BMS-378806
BMS-378806 is a potent HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
Product Specifications
CAS Number
357263-13-9
Product Name Alternative
BMS-806
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/BMS-378806.html
Concentration
10mM
Purity
98.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=C2C(NC=C2C(C(N3CCN(C[C@H]3C)C(C4=CC=CC=C4)=O)=O)=O)=NC=C1
Molecular Formula
C22H22N4O4
Molecular Weight
406.43
References & Citations
[1]Wang T, et al. Discovery of 4-benzoyl-1-[ (4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl) oxoacetyl]-2- (R) -methylpiperazine (BMS-378806) : a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. J Med Chem. 2003 Sep 25;46 (20) :4236-9.|[2]Ho HT, et al. Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events. J Virol. 2006 Apr;80 (8) :4017-25.|[3]Guo Q, et al. Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions. J Virol. 2003 Oct;77 (19) :10528-36
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1; HIV-2
Available Sizes
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