BMS-378806

BMS-378806 is a potent HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.

Product Specifications

CAS Number

[357263-13-9]

Product Name Alternative

BMS-806

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/BMS-378806.html

Concentration

10mM

Purity

98.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=C2C(NC=C2C(C(N3CCN(C[C@H]3C)C(C4=CC=CC=C4)=O)=O)=O)=NC=C1

Molecular Formula

C22H22N4O4

Molecular Weight

406.43

References & Citations

[1]Wang T, et al. Discovery of 4-benzoyl-1-[ (4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl) oxoacetyl]-2- (R) -methylpiperazine (BMS-378806) : a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. J Med Chem. 2003 Sep 25;46 (20) :4236-9.|[2]Ho HT, et al. Envelope conformational changes induced by human immunodeficiency virus type 1 attachment inhibitors prevent CD4 binding and downstream entry events. J Virol. 2006 Apr;80 (8) :4017-25.|[3]Guo Q, et al. Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions. J Virol. 2003 Oct;77 (19) :10528-36