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PDCD6 Antibody

Product Specifications

Background

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.

NCBI Gene ID

10016

Swiss Prot

O75340

Accession Number

O75340

Host

Rabbit

Reactivity

Human

Immunogen

This PDCD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human PDCD6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-784

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PDCD6

NCBI Official Name

Programmed cell death protein 6

NCBI Organism

Homo sapiens

Background Reference 01

Vergarajauregui, S., et al. J. Biol. Chem. 284 (52) :36357-36366 (2009)

Background Reference 02

Okumura, M., et al. Biochem. Biophys. Res. Commun. 386 (1) :237-241 (2009)

Background Reference 03

Suzuki, H., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 64 (PT 11), 974-977 (2008) :

Background Reference 04

Yamada, Y., et al. Cancer Sci. 99 (11) :2193-2199 (2008)

Other Product Names

Programmed cell death protein 6, Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2, PDCD6, ALG2

Tested Applications

WB

Physical Properties

Liquid

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