UBE2L3 Antibody

Product Specifications

Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) . This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.

NCBI Gene ID

7332

Swiss Prot

P68036

Accession Number

P68036

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This UBE2L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the C-terminal region of human UBE2L3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

18 kDa

Fragment

Rabbit Ig

Symbol

UBE2L3

NCBI Official Name

Ubiquitin-conjugating enzyme E2 L3

NCBI Organism

Homo sapiens

Background Reference 01

Fransen, K., et al. Hum. Mol. Genet. 19 (17) :3482-3488 (2010)

Background Reference 02

Dubois, P.C., et al. Nat. Genet. 42 (4) :295-302 (2010)

Background Reference 03

Kamatani, Y., et al. Nat. Genet. 42 (3) :210-215 (2010)

Background Reference 04

Purbeck, C., et al. Biochemistry 49 (7) :1361-1363 (2010)

Other Product Names

Ubiquitin-conjugating enzyme E2 L3, L-UBC, UbcH7, Ubiquitin carrier protein L3, Ubiquitin-conjugating enzyme E2-F1, Ubiquitin-protein ligase L3, UBE2L3, UBCE7, UBCH7