KIRREL Antibody

Product Specifications

Background

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762) . The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]) .

NCBI Gene ID

55243

Swiss Prot

Q96J84

Accession Number

Q96J84

Host

Rabbit

Reactivity

Human

Immunogen

This KIRREL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human KIRREL.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

84 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

KIRREL

NCBI Official Name

Kin of IRRE-like protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Machuca, E., et al. J. Am. Soc. Nephrol. 21 (7) :1209-1217 (2010)

Background Reference 02

Wagner, M.C., et al. J. Biol. Chem. 283 (51) :35579-35589 (2008)

Background Reference 03

Hartleben, B., et al. J. Biol. Chem. 283 (34) :23033-23038 (2008)

Background Reference 04

Harita, Y., et al. J. Biol. Chem. 283 (14) :9177-9186 (2008)

Other Product Names

Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, KIRREL1, NEPH1

Tested Applications

Protein ID

54036152

Physical Properties

Liquid

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