EGFR Antibody

Product Specifications

Background

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

NCBI Gene ID

1956

Swiss Prot

P00533

Accession Number

P00533

Host

Rabbit

Reactivity

Human

Immunogen

This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the N-terminal region of human EGFR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Chicken

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

134 kDa

Fragment

Rabbit Ig

Symbol

EGFR

NCBI Official Name

Epidermal growth factor receptor

NCBI Organism

Homo sapiens

Background Reference 01

Abdallah, R.T., et al. J. Biol. Chem. 285 (45) :35206-35215 (2010)

Background Reference 02

Lu, C., et al. Mol. Cell. Biol. 30 (22) :5432-5443 (2010)

Background Reference 03

Rosell, R., et al. Ann. N. Y. Acad. Sci. 1210, 45-52 (2010) :

Background Reference 04

Hata, A., et al.Thorac Oncol 5 (10) :1524-1528 (2010)

Other Product Names

Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1

Tested Applications

WB, IHC-P

Protein ID

2811086

Physical Properties

Liquid

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