NDUFS6 Antibody

Product Specifications

Background

This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.

NCBI Gene ID

4726

Swiss Prot

O75380

Accession Number

O75380

Host

Rabbit

Reactivity

Human

Immunogen

This NDUFS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the Central region of human NDUFS6.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

14 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NDUFS6

NCBI Official Name

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Saito, A., et al. J. Hum. Genet. 54 (6) :317-323 (2009)

Background Reference 02

Martins-de-Souza, D., et al.Neural Transm 116 (3) :275-289 (2009)

Background Reference 03

Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17 (12) :3558-3566 (2008)

Background Reference 04

Starr, J.M., et al. Mech. Ageing Dev. 129 (12) :745-751 (2008)

Other Product Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial, Complex I-13kD-A, CI-13kD-A, NADH-ubiquinone oxidoreductase 13 kDa-A subunit, NDUFS6