NXT1 Antibody

Product Specifications

Background

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein) - and CRM1 (required for chromosome region maintenance) -dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

NCBI Gene ID

29107

Swiss Prot

Q9UKK6

Accession Number

Q9UKK6

Host

Rabbit

Reactivity

Mouse

Immunogen

This NXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the C-terminal region of human NXT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

16 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NXT1

NCBI Official Name

NTF2-related export protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

Background Reference 02

Forler, D., et al. Nat. Biotechnol. 21 (1) :89-92 (2003)

Background Reference 03

Katahira, J., et al. J. Biol. Chem. 277 (11) :9242-9246 (2002)

Background Reference 04

Wiegand, H.L., et al. Mol. Cell. Biol. 22 (1) :245-256 (2002)

Other Product Names

NTF2-related export protein 1, Protein p15, NXT1

Tested Applications

Protein ID

18203504

Physical Properties

Liquid

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