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ASCL1 Antibody

Product Specifications

Background

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3') . Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

NCBI Gene ID

429

Swiss Prot

P50553

Accession Number

P50553

Host

Rabbit

Reactivity

Human

Immunogen

This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-683

Calculated Molecular Weight

25 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ASCL1

NCBI Official Name

Achaete-scute homolog 1

NCBI Organism

Homo sapiens

Background Reference 01

Phi, J.H., et al.Neurosurg Pediatr 5 (6) :608-614 (2010)

Background Reference 02

McGaughey, D.M., et al. Genomics 95 (6) :363-369 (2010)

Background Reference 03

Li, F., et al. Zhongguo Fei Ai Za Zhi 13 (4) :317-321 (2010)

Background Reference 04

Deng, H., et al. Biochem. Biophys. Res. Commun. 392 (4) :548-550 (2010)

Other Product Names

Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1

Tested Applications

WB

Protein ID

20455478

Physical Properties

Liquid

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