PPP2R1A Antibody

Product Specifications

Background

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq].

NCBI Gene ID

5518

Swiss Prot

P30153

Accession Number

P30153

Host

Rabbit

Reactivity

Human

Immunogen

This PPP2R1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-481 amino acids from the C-terminal region of human PPP2R1A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

65 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PPP2R1A

NCBI Official Name

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

NCBI Organism

Homo sapiens

Background Reference 01

Jones, S., et al. Science 330 (6001) :228-231 (2010)

Background Reference 02

Schmitz, M.H., et al. Nat. Cell Biol. 12 (9) :886-893 (2010)

Background Reference 03

Heikkinen, P.T., et al. J. Biol. Chem. 285 (6) :3740-3749 (2010)

Background Reference 04

Dupont, W.D., et al. Cancer 116 (1) :8-19 (2010)

Other Product Names

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha, PPP2R1A