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GATM Antibody

Product Specifications

Background

This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.

NCBI Gene ID

2628

Swiss Prot

P50440

Accession Number

P50440

Host

Rabbit

Reactivity

Human

Immunogen

This GATM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-378 amino acids from the C-terminal region of human GATM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-678

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

GATM

NCBI Official Name

Glycine amidinotransferase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Kottgen, A., et al. Nat. Genet. 42 (5) :376-384 (2010)

Background Reference 02

Kottgen, A., et al. Nat. Genet. 41 (6) :712-717 (2009)

Background Reference 03

Lion-Francois, L., et al. Neurology 67 (9) :1713-1714 (2006)

Background Reference 04

Cullen, M.E., et al. Circulation 114 (1 SUPPL), I16-I20 (2006) :

Other Product Names

Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, Transamidinase, GATM, AGAT

Tested Applications

WB

Protein ID

1730201

Physical Properties

Liquid

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