COLQ Antibody

Product Specifications

Background

This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

8292

Swiss Prot

Q9Y215

Accession Number

Q9Y215

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This COLQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-353 amino acids from the C-terminal region of human COLQ.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

COLQ

NCBI Official Name

Acetylcholinesterase collagenic tail peptide

NCBI Organism

Homo sapiens

Background Reference 01

Mihaylova, V., et al. Brain 131 (PT 3), 747-759 (2008) :

Background Reference 02

Schreiner, F., et al. Neuromuscul. Disord. 17 (3) :262-265 (2007)

Background Reference 03

Ting, A.K., et al. Chem. Biol. Interact. 157-158, 63-70 (2005) :

Background Reference 04

Dvir, H., et al. EMBO J. 23 (22) :4394-4405 (2004)

Other Product Names

Acetylcholinesterase collagenic tail peptide, AChE Q subunit, Acetylcholinesterase-associated collagen, COLQ

Tested Applications

Protein ID

116241309

Physical Properties

Liquid

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