Dcr-1 Antibody
Product Specifications
Background
The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
NCBI Gene ID
176138
Swiss Prot
P34529
Accession Number
P34529
Host
Rabbit
Reactivity
C. elegans
Immunogen
This Dcr-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1068-1097 amino acids from the Central region of human Dcr-1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
218 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Dcr-1
NCBI Official Name
Endoribonuclease dcr-1
NCBI Organism
Caenorhabditis elegans
Background Reference 01
Duchaine TF, et al. 2006. Cell 124:343-354.
Background Reference 02
Denli AM, et al. 2004. Nature 432:231-235.
Background Reference 03
Tabara H, et al. 2002. Cell 109:861-871.
Background Reference 04
Grishok A, et al. 2001. Cell 106:23-34.
Other Product Names
Endoribonuclease dcr-1, 3126-, dcr-1
Tested Applications
WB
Physical Properties
Liquid
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