RMP Antibody

Product Specifications

Background

The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

NCBI Gene ID

8725

Swiss Prot

O94763

Accession Number

O94763

Host

Rabbit

Reactivity

Human

Immunogen

This RMP (URI) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-376 amino acids from the C-terminal region of human RMP (URI) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

URI1

NCBI Official Name

Unconventional prefoldin RPB5 interactor 1

NCBI Organism

Homo sapiens

Background Reference 01

Delgermaa, L., et al., Mol. Cell. Biol. 24 (19) :8556-8566 (2004) .

Background Reference 02

Gstaiger, M., et al., Science 302 (5648) :1208-1212 (2003) .

Background Reference 03

Van Leuven, F., et al., Genomics 54 (3) :511-520 (1998) .

Background Reference 04

Dorjsuren, D., et al., Mol. Cell. Biol. 18 (12) :7546-7555 (1998) .

Other Product Names

Unconventional prefoldin RPB5 interactor 1, Protein NNX3, Protein phosphatase 1 regulatory subunit 19, RNA polymerase II subunit 5-mediating protein, RPB5-mediating protein, URI1, C19orf2, NNX3, PPP1R19, RMP, URI