FADD Antibody
Product Specifications
Background
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
NCBI Gene ID
8772
Swiss Prot
Q13158
Accession Number
Q13158
Host
Rabbit
Reactivity
Human
Immunogen
This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Inflammasomes
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
23 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FADD
NCBI Official Name
FAS-associated death domain protein
NCBI Organism
Homo sapiens
Background Reference 01
Hindryckx, P., et al. J. Immunol. 185 (10) :6306-6316 (2010)
Background Reference 02
Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)
Background Reference 03
Papoff, G., et al. Biochim. Biophys. Acta 1803 (8) :898-911 (2010)
Background Reference 04
Li, P., et al. J. Biol. Chem. 285 (29) :22713-22722 (2010)
Other Product Names
FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Tested Applications
WB
Protein ID
2498355
Physical Properties
Liquid
Frequently Asked Questions
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