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FADD Antibody

Product Specifications

Background

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

NCBI Gene ID

8772

Swiss Prot

Q13158

Accession Number

Q13158

Host

Rabbit

Reactivity

Human

Immunogen

This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Inflammasomes

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-625

Calculated Molecular Weight

23 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

FADD

NCBI Official Name

FAS-associated death domain protein

NCBI Organism

Homo sapiens

Background Reference 01

Hindryckx, P., et al. J. Immunol. 185 (10) :6306-6316 (2010)

Background Reference 02

Silva, L.K., et al. Eur. J. Hum. Genet. 18 (11) :1221-1227 (2010)

Background Reference 03

Papoff, G., et al. Biochim. Biophys. Acta 1803 (8) :898-911 (2010)

Background Reference 04

Li, P., et al. J. Biol. Chem. 285 (29) :22713-22722 (2010)

Other Product Names

FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1

Tested Applications

WB

Protein ID

2498355

Physical Properties

Liquid

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