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CTNNB1 Antibody

Product Specifications

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

NCBI Gene ID

1499

Swiss Prot

P35222

Accession Number

P35222

Host

Rabbit

Reactivity

Human

Immunogen

This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-751 amino acids from the C-terminal region of human CTNNB1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-609

Calculated Molecular Weight

85 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CTNNB1

NCBI Official Name

Catenin beta-1

NCBI Organism

Homo sapiens

Background Reference 01

Huang, W., et al. Mol. Cell. Biol. 30 (19) :4575-4594 (2010)

Background Reference 02

Chairoungdua, A., et al. J. Cell Biol. 190 (6) :1079-1091 (2010)

Background Reference 03

Mirza, M.K., et al. J. Exp. Med. 207 (8) :1675-1685 (2010)

Background Reference 04

Guo, Q., et al. Acta Biochim. Biophys. Sin. (Shanghai) 42 (7) :450-456 (2010)

Other Product Names

Catenin beta-1, Beta-catenin, CTNNB1, CTNNB

Tested Applications

WB

Protein ID

461854

Physical Properties

Liquid

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