LONP1 Antibody

Product Specifications

Background

This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription.

NCBI Gene ID

9361

Swiss Prot

P36776

Accession Number

P36776

Host

Rabbit

Reactivity

Human

Immunogen

This LONP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-418 amino acids from the Central region of human LONP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

106 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

LONP1

NCBI Official Name

Lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}

NCBI Organism

Homo sapiens

Background Reference 01

Hansen, J., et al. Neurobiology 153 (2) :474-482 (2008)

Background Reference 02

Chen, S.H., et al. Nucleic Acids Res. 36 (4) :1273-1287 (2008)

Background Reference 03

Bogenhagen, D.F., et al. J. Biol. Chem. 283 (6) :3665-3675 (2008)

Background Reference 04

Bayot, A., et al. Biochimie 90 (2) :260-269 (2008)

Other Product Names

Lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}, 3421- {ECO:0000255|HAMAP-Rule:MF_03120}, LONHs, Lon protease-like protein {ECO:0000255|HAMAP-Rule:MF_03120}, LONP {ECO:0000255|HAMAP-Rule:MF_03120}, Mitochondrial ATP-dependent protease Lon {ECO:0000255|HAMAP-Rule:MF_03120}, Serine protease 15 {ECO:0000255|HAMAP-Rule:MF_03120}, LONP1 {ECO:0000255|HAMAP-Rule:MF_03120}, PRSS15