TRIM22 Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.
NCBI Gene ID
10346
Swiss Prot
Q8IYM9
Accession Number
Q8IYM9
Host
Rabbit
Reactivity
Human
Immunogen
This TRIM22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human TRIM22.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TRIM22
NCBI Official Name
E3 ubiquitin-protein ligase TRIM22
NCBI Organism
Homo sapiens
Background Reference 01
Kajaste-Rudnitski, A., et al. Amino Acids 39 (1) :1-9 (2010)
Background Reference 02
Petersson, J., et al. Exp. Cell Res. 316 (4) :568-579 (2010)
Background Reference 03
Ovsyannikova, I.G., et al. Hum. Genet. 127 (2) :207-221 (2010)
Background Reference 04
Ovsyannikova, I.G., et al. J. Infect. Dis. 201 (2) :207-213 (2010)
Other Product Names
E3 ubiquitin-protein ligase TRIM22, 632-, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22, TRIM22, RNF94, STAF50
Tested Applications
WB
Protein ID
47606181
Physical Properties
Liquid
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