TRIM22 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.

NCBI Gene ID

10346

Swiss Prot

Q8IYM9

Accession Number

Q8IYM9

Host

Rabbit

Reactivity

Human

Immunogen

This TRIM22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human TRIM22.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

57 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

TRIM22

NCBI Official Name

E3 ubiquitin-protein ligase TRIM22

NCBI Organism

Homo sapiens

Background Reference 01

Kajaste-Rudnitski, A., et al. Amino Acids 39 (1) :1-9 (2010)

Background Reference 02

Petersson, J., et al. Exp. Cell Res. 316 (4) :568-579 (2010)

Background Reference 03

Ovsyannikova, I.G., et al. Hum. Genet. 127 (2) :207-221 (2010)

Background Reference 04

Ovsyannikova, I.G., et al. J. Infect. Dis. 201 (2) :207-213 (2010)

Other Product Names

E3 ubiquitin-protein ligase TRIM22, 632-, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22, TRIM22, RNF94, STAF50