ESR2 Antibody

Product Specifications

Background

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

NCBI Gene ID

2100

Swiss Prot

Q92731

Accession Number

Q92731

Host

Rabbit

Reactivity

Human

Immunogen

This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-480 amino acids from the C-terminal region of human ESR2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

59 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

ESR2

NCBI Official Name

Estrogen receptor beta

NCBI Organism

Homo sapiens

Background Reference 01

Fang, Y.J., et al. Tumour Biol. 31 (6) :651-658 (2010) Hayes, D.F., et al. Clin. Pharmacol. Ther. 88 (5) :626-629 (2010) Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) Wurster, M., et al. Oncol. Rep. 24 (3) :653-659 (2010) Paulus, J.K., et al. Lung Cancer (2010) In press :