RGS13 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.

NCBI Gene ID

6003

Swiss Prot

O14921

Accession Number

O14921

Host

Rabbit

Reactivity

Human

Immunogen

This RGS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the Central region of human RGS13.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

19 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RGS13

NCBI Official Name

Regulator of G-protein signaling 13

NCBI Organism

Homo sapiens

Background Reference 01

Wang, J., et al. Carcinogenesis 31 (10) :1755-1761 (2010)

Background Reference 02

Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :

Background Reference 03

Bansal, G., et al. J. Immunol. 181 (11) :7882-7890 (2008)

Background Reference 04

Han, J.I., et al. J. Leukoc. Biol. 79 (6) :1357-1368 (2006)

Other Product Names

Regulator of G-protein signaling 13, RGS13, RGS13

Tested Applications

Physical Properties

Liquid

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