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CCNDBP1 Antibody

Product Specifications

Background

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq].

NCBI Gene ID

23582

Swiss Prot

O95273

Accession Number

O95273

Host

Rabbit

Reactivity

Human

Immunogen

This CCNDBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human CCNDBP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

40 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CCNDBP1

NCBI Official Name

Cyclin-D1-binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Lee, I., et al. Cancer Res. 70 (11) :4357-4365 (2010)

Background Reference 02

Seto, A., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 65 (PT 1), 21-24 (2009) :

Background Reference 03

Ikushima, H., et al. EMBO J. 27 (22) :2955-2965 (2008)

Background Reference 04

Chen, W.C., et al. Histopathology 53 (5) :554-560 (2008)

Other Product Names

Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM

Tested Applications

WB

Physical Properties

Liquid

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