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NEIL3 Antibody

Product Specifications

Background

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]) .

NCBI Gene ID

55247

Swiss Prot

Q8TAT5

Accession Number

Q8TAT5

Host

Rabbit

Reactivity

Human

Immunogen

This NEIL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human NEIL3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NEIL3

NCBI Official Name

Endonuclease 8-like 3

NCBI Organism

Homo sapiens

Background Reference 01

Krokeide, S.Z., et al. Protein Expr. Purif. 65 (2) :160-164 (2009)

Background Reference 02

Takao, M., et al. Genes Cells 14 (2) :261-270 (2009)

Background Reference 03

Dallosso, A.R., et al. Gut 57 (9) :1252-1255 (2008)

Background Reference 04

Bethke, L., et al. J. Natl. Cancer Inst. 100 (4) :270-276 (2008)

Other Product Names

Endonuclease 8-like 3, 322-, DNA glycosylase FPG2, DNA glycosylase/AP lyase Neil3, Endonuclease VIII-like 3, Nei-like protein 3, NEIL3

Tested Applications

WB

Protein ID

302393810

Physical Properties

Liquid

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