SKP1 Antibody

Product Specifications

Background

SKP1A is an F-box protein which functions as a substrate recognition component of the SCF ubiquitin ligase complex. It binds to cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin proteolysis through an F-box motif. SKP1A also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor.

NCBI Gene ID

6500

Swiss Prot

P63208

Accession Number

P63208

Host

Rabbit

Reactivity

Human

Immunogen

This SKP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids from the Central region of human SKP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Monkey, Mouse, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

19 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SKP1

NCBI Official Name

S-phase kinase-associated protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Wu, G., et al., Mol. Cell 11 (6) :1445-1456 (2003) .

Background Reference 02

Piva, R., et al., Mol. Cell. Biol. 22 (23) :8375-8387 (2002) .

Background Reference 03

Matsuzawa, S.I., et al., Mol. Cell 7 (5) :915-926 (2001) .

Background Reference 04

Schulman, B.A., et al., Nature 408 (6810) :381-386 (2000) .

Other Product Names

S-phase kinase-associated protein 1, Cyclin-A/CDK2-associated protein p19, p19A, Organ of Corti protein 2, OCP-2, Organ of Corti protein II, OCP-II, RNA polymerase II elongation factor-like protein, SIII, Transcription elongation factor B polypeptide 1-like, p19skp1, SKP1, EMC19, OCP2, SKP1A, TCEB1L