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AKTIP Antibody

Product Specifications

Background

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB) /Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

NCBI Gene ID

64400

Swiss Prot

Q9H8T0

Accession Number

Q9H8T0

Host

Rabbit

Reactivity

Human

Immunogen

This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-501

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

AKTIP

NCBI Official Name

AKT-interacting protein

NCBI Organism

Homo sapiens

Background Reference 01

Notaridou, M., et al. Int. J. Cancer (2010) In press :

Background Reference 02

Quaye, L., et al. Hum. Mol. Genet. 18 (10) :1869-1878 (2009)

Background Reference 03

Xu, L., et al. Mol. Biol. Cell 19 (12) :5059-5071 (2008)

Background Reference 04

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Other Product Names

AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS

Tested Applications

WB

Protein ID

54035954

Physical Properties

Liquid

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