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RNF128 Antibody

Product Specifications

Background

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

NCBI Gene ID

79589

Swiss Prot

Q8TEB7

Accession Number

Q8TEB7

Host

Rabbit

Reactivity

Human

Immunogen

This RNF128 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human RNF128.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

RNF128

NCBI Official Name

E3 ubiquitin-protein ligase RNF128

NCBI Organism

Homo sapiens

Background Reference 01

Su, L.L., et al. J. Immunol. 183 (1) :438-444 (2009)

Background Reference 02

Lin, J.T., et al. J. Immunol. 182 (10) :5919-5928 (2009)

Background Reference 03

Lineberry, N., et al. J. Biol. Chem. 283 (42) :28497-28505 (2008)

Background Reference 04

Egawa, S., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (1), G163-G169 (2008) :

Other Product Names

E3 ubiquitin-protein ligase RNF128, 632-, Gene related to anergy in lymphocytes protein, GRAIL, RING finger protein 128, RNF128

Tested Applications

WB

Protein ID

74751443

Physical Properties

Liquid

Frequently Asked Questions

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