Mouse Khdrbs1 Antibody

Product Specifications

Background

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.

NCBI Gene ID

20218

Swiss Prot

Q60749

Accession Number

Q60749

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Khdrbs1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-443 amino acids from the C-terminal region of mouse Khdrbs1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Human, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Khdrbs1

NCBI Official Name

KH domain-containing, RNA-binding, signal transduction-associated protein 1

NCBI Organism

Mus musculus

Background Reference 01

Sette, C., et al. J. Androl. 31 (1) :66-74 (2010)

Background Reference 02

Maroni, P., et al. Mol. Cell. Endocrinol. 309 (1-2), 26-31 (2009) :

Background Reference 03

Paronetto, M.P., et al. J. Cell Biol. 185 (2) :235-249 (2009)

Background Reference 04

Huot, M.E., et al. Mol. Cell. Biol. 29 (7) :1933-1943 (2009)

Other Product Names

KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, Sam68, p21 Ras GTPase-activating protein-associated p62, p68, Khdrbs1 {ECO:0000312|MGI:MGI:893579}