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Mouse Derl2 Antibody

Product Specifications

Background

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity) .

NCBI Gene ID

116891

Swiss Prot

Q8BNI4

Accession Number

Q8BNI4

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Derl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of mouse Derl2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-461

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Derl2

NCBI Official Name

Derlin-2

NCBI Organism

Mus musculus

Background Reference 01

Schaheen, B., et al. J. Cell. Sci. 122 (PT 13), 2228-2239 (2009) :

Background Reference 02

Oda, Y., et al. J. Cell Biol. 172 (3) :383-393 (2006)

Background Reference 03

Lilley, B.N., et al. Proc. Natl. Acad. Sci. U.S.A. 102 (40) :14296-14301 (2005)

Background Reference 04

Kaput, J., et al. Physiol. Genomics 18 (3) :316-324 (2004)

Other Product Names

Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LANa, Derl2, Der2, Flana

Tested Applications

WB

Physical Properties

Liquid

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