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EIF2B3 Antibody

Product Specifications

Background

EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.

NCBI Gene ID

8891

Swiss Prot

Q9NR50

Accession Number

Q9NR50

Host

Rabbit

Reactivity

Human

Immunogen

This EIF2B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-376 amino acids from the C-terminal region of human EIF2B3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-457

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

EIF2B3

NCBI Official Name

Translation initiation factor eIF-2B subunit gamma

NCBI Organism

Homo sapiens

Background Reference 01

Van der Knaap, M.S., et al., Ann. Neurol. 51 (2) :264-270 (2002) .

Background Reference 02

Kruger, M., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (15) :8566-8571 (2000) .

Background Reference 03

Gomez, E., et al., Mol. Cell. Biol. 20 (11) :3965-3976 (2000) .

Other Product Names

Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma, EIF2B3

Tested Applications

WB

Protein ID

18203317

Physical Properties

Liquid

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