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PGR/PR Antibody

Product Specifications

Background

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.

NCBI Gene ID

5241

Swiss Prot

P06401

Accession Number

P06401

Host

Rabbit

Reactivity

Human

Immunogen

This PGR/PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human PGR/PR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-418

Calculated Molecular Weight

99 kDa

Fragment

Rabbit Ig

Symbol

PGR

NCBI Official Name

Progesterone receptor

NCBI Organism

Homo sapiens

Background Reference 01

Geradts, J., et al. Cancer Invest. 28 (9) :969-977 (2010)

Background Reference 02

Tang, P., et al. Cancer Invest. 28 (9) :978-982 (2010)

Background Reference 03

Van Belle, V., et al. J. Clin. Oncol. 28 (27) :4129-4134 (2010)

Background Reference 04

Taylor, K.C., et al. Horm Res Paediatr (2010) In press :

Other Product Names

Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3

Tested Applications

WB, IF

Protein ID

90110048

Physical Properties

Liquid

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