AMOT Antibody
Product Specifications
Background
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
154796
Swiss Prot
Q4VCS5
Accession Number
Q4VCS5
Host
Rabbit
Reactivity
Human
Immunogen
This AMOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-312 amino acids from the Central region of human AMOT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
118 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:500-1:1000
Symbol
AMOT
NCBI Official Name
Angiomotin
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Heller, B., et al. J. Biol. Chem. 285 (16) :12308-12320 (2010)
Background Reference 03
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Background Reference 04
Gagne, V., et al. Cell Motil. Cytoskeleton 66 (9) :754-768 (2009)
Other Product Names
Angiomotin, AMOT, KIAA1071
Tested Applications
WB
Protein ID
74753814
Physical Properties
Liquid
Curated Selection
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