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IL5RA Antibody

Product Specifications

Background

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.

NCBI Gene ID

3568

Swiss Prot

Q01344

Accession Number

Q01344

Host

Rabbit

Reactivity

Human

Immunogen

This IL5RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human IL5RA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-404

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

IL5RA

NCBI Official Name

Interleukin-5 receptor subunit alpha

NCBI Organism

Homo sapiens

Background Reference 01

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

Background Reference 02

Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

Background Reference 03

Beckers, M.M., et al. Eur. J. Intern. Med. 21 (4) :289-292 (2010)

Background Reference 04

Schuurhof, A., et al. Pediatr. Pulmonol. 45 (6) :608-613 (2010)

Other Product Names

Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CDw125, CD125, IL5RA, IL5R

Tested Applications

WB

Protein ID

116242525

Physical Properties

Liquid

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