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DMRT1 Antibody

Product Specifications

Background

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain) . The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.

NCBI Gene ID

1761

Swiss Prot

Q9Y5R6

Accession Number

Q9Y5R6

Host

Rabbit

Reactivity

Human

Immunogen

This DMRT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the C-terminal region of human DMRT1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

39 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

DMRT1

NCBI Official Name

Doublesex- and mab-3-related transcription factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Kang, J.U., et al. Int. J. Oncol. 37 (2) :327-335 (2010)

Background Reference 02

Turnbull, C., et al. Nat. Genet. 42 (7) :604-607 (2010)

Background Reference 03

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 04

Krentz, A.D., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (52) :22323-22328 (2009)

Other Product Names

Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1, DMT1

Tested Applications

WB

Protein ID

83305820

Physical Properties

Liquid

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