NUP50 Antibody

Product Specifications

Background

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. NUP50 may serve as a binding site on the nuclear side of the pore complex for export receptor-cargo complexes. It interacts with multiple transport receptor proteins including p27Kip1. This interaction is required for correct intracellular transport and degradation of p27Kip1.

NCBI Gene ID

10762

Swiss Prot

Q9UKX7

Accession Number

Q9UKX7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This NUP50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human NUP50.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

50 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

NUP50

NCBI Official Name

Nuclear pore complex protein Nup50

NCBI Organism

Homo sapiens

Background Reference 01

Lindsay, M.E., et al., Cell 110 (3) :349-360 (2002) .

Background Reference 02

Swaminathan, S., et al., Dev. Cell 3 (3) :304-306 (2002) .

Background Reference 03

Smitherman, M., et al., Mol. Cell. Biol. 20 (15) :5631-5642 (2000) .

Background Reference 04

Guan, T., et al., Mol. Cell. Biol. 20 (15) :5619-5630 (2000) .

Other Product Names

Nuclear pore complex protein Nup50, 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50, NUP50, NPAP60L

Tested Applications

Protein ID

20455193

Physical Properties

Liquid

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