SLC25A20 Antibody

Product Specifications

Background

This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants.

NCBI Gene ID

788

Swiss Prot

O43772

Accession Number

O43772

Host

Rabbit

Reactivity

Mouse

Immunogen

This SLC25A20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from the C-terminal region of human SLC25A20.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

33 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

SLC25A20

NCBI Official Name

Mitochondrial carnitine/acylcarnitine carrier protein

NCBI Organism

Homo sapiens

Background Reference 01

Tachibana, K., et al. Biochem. Biophys. Res. Commun. 389 (3) :501-505 (2009)

Background Reference 02

De Lucas, J.R., et al. Mol. Membr. Biol. 25 (2) :152-163 (2008)

Background Reference 03

Pierre, G., et al. J. Inherit. Metab. Dis. 30 (5), 815 (2007) :

Background Reference 04

Peluso, G., et al. J. Cell. Physiol. 203 (2) :439-446 (2005)

Other Product Names

Mitochondrial carnitine/acylcarnitine carrier protein, Carnitine/acylcarnitine translocase, CAC, Solute carrier family 25 member 20, SLC25A20, CAC, CACT